草莓可能有助于预防老年痴呆症

2022年7月20日,星期三

Could strawberries in your cereal, salad or smoothie help protect your brain from Alzheimer’s? Maybe so, according to a new study from researchers at RUSH.

The researchers found that a bioactive compound found in strawberries called pelargonidin may be associated with fewer neurofibrillary tau tangles in the brain. Tau缠结是人类的标志之一 阿尔茨海默病, which is caused by abnormal changes with tau proteins that accumulate in the brain. The study was published in the Journal of Alzheimer’s Disease on July 19.

“We suspect the anti-inflammatory properties of pelargonidin may decrease overall neuroinflammation, 这可能会减少细胞因子的产生,研究作者说。 朱莉·施耐德,医学博士,硕士 an associate professor and neuropathologist with the RUSH Alzheimer’s Disease Center.

Cytokines are proteins produced by cells, and they can regulate various inflammatory responses. Inflammation in the brain has been linked to Alzheimer’s pathology such as plaques and tangles. The data suggests that pelargonidin may protect the aging brain from developing 阿尔茨海默病 pathology.

草莓中富含的化合物

Among berries, strawberries are the most abundant source of pelargonidin.

“While pelargonidin should be examined further for their role in maintaining brain health in older adults, this gives a simple change that anyone can make in their diet,RADC营养流行病学家说 供阿加瓦尔博士, an author of the study and assistant professor of internal medicine at RUSH.

RUSH researchers looked at data they acquired from an ongoing long-term study conducted by the RADC’s 记忆与老化项目,始于1997年. There were a total of 575 deceased participants with complete dietary information during the follow-up and brain autopsies whose average age of death was 91.3年. A total of 452 people were non-carriers of the APOE 4 gene and a total of 120 participants with APOE 4, which is the strongest genetic risk factor gene for 阿尔茨海默病. Participants were assessed about diet using a food frequency questionnaire for up to nearly 20 years of follow-up prior to death and standardized neuropathological evaluation after death.

在研究过程中, 每人每年收到, standardized testing for cognitive ability in five areas — episodic memory, 工作记忆, 语义记忆, 视觉空间能力和感知速度.

“研究给了银河电玩城希望”

The 记忆与老化项目 includes people age 65 and older who were residents of more than 40 retirement communities and senior public housing units across northern Illinois. Those who enrolled were mostly white without known dementia, and all participants agreed to undergo annual clinical evaluations while alive and a brain autopsy after death. The results were the same after researchers adjusted for other factors that could affect memory and thinking skills, 如教育, APOE - 4状态, 维生素E, 和维生素C. The associations were more robust among those without dementia or mild cognitive impairment at baseline.

“We did not observe the same effect in people with the APOE 4 gene that is associated with 阿尔茨海默病, but that may be due to the smaller sample size of individuals in this study who had the gene,阿格沃尔说.

“The study was an observational study and does not prove a direct causal relationship. Further research is needed to understand the role of nutrition in Alzheimer’s Disease, but this study gives us hope on how specific dietary components such as berries may help brain health,阿格沃尔说.